Spontaneous Aortic Lesions in Rabbits
نویسنده
چکیده
Lesions in the rabbit aorta that occur spontaneously and contain no lipid consist of intimal mesenchymal proliferation and of medial sclerosis. Although the relationship of diet-induced atheroma to the intimal mesenchymal alterations is still not clear, our experiments have established that (a) the morphologic characteristics of diet-induced atheroma and of the spontaneous medial lesions are dissimilar at all stages of their development, and (b) the presence of spontaneous medial lesions clearly influences the development of atheroma. This influence is related to (a) an increased tendency for atheroma formation at the raised proximal and lateral borders of nodular medial lesions projecting from the luminal surface, (b) the absence of atheroma formation at sites of medial calcification, and (c) a propensity for lipid deposition in areas of acid mueopolysaccharide accumulation within spontaneous medial lesions. ADDITIONAL
منابع مشابه
Aging influences development and progression of early aortic atherosclerotic lesions in cholesterol-fed rabbits.
The arterial wall in aged animals shows an increased susceptibility to develop atherosclerotic lesions, although the mechanisms by which aging acts are still unclear. We investigated early aortic lesions in aged rabbits (5 to 6 years old, AH group) and young rabbits (2 months old, YH group) after 2 months of 0.2% cholesterol feeding. Fatty streaks or spots mainly in the proximal segments occupi...
متن کاملTHE EFFECT OF ANTIHYPERTENSIVE DRUGS IN THE SUPPRESSION OF ATHEROSCLEROSIS
The present investigation was undertaken to evaluate the effect of antihypertensive drugs on aortic atherogenesis in hypercholesterolemic rabbits. In enalapril and nifedipine treated rabbits aortic atherosclerotic plaque involvement was significantly decreased (p<0. Oland p<O. 05, respectively) as compared to the control group. However, in hydrochlorothiazide treated rabbits aortic atheroge...
متن کاملPotentiation of atherosclerotic lesions in rabbits by a high dietary level of vitamin E.
1. Two experiments were conducted to determine whether or not high dietary levels of vitamin E affect the development of atherosclerotic lesions in aortas of cholesterol-fed (5 g/kg diet) rabbits that were mechanically deendothelialized by balloon catheterization. 2. In the first experiment, the aortas of rabbits fed 2000 mg vitamin E/kg diet (i.e. 50-fold their nutritional requirement) for 8 w...
متن کاملComparison of the lipid compositions of the aortic lesions in rabbits given different atherogenic diets.
I . The compositions of the lipids in the atheromatous lesions of rabbits have been studied in an experiment in which two groups of rabbits (twelvelgroup) were given different atherogenic diets for a period of 38 weeks. One group of rabbits was given a diet in which 35 % of the total calories was derived from butterfat and the other group was given a diet in which 48 yo of the total calories wa...
متن کامل